For Patients Who are Experiencing Clinically Significant Angiokeratomas
The LOTU Trial is investigating whether
you
may see a prolonged reduction in the visibility or burden of lesions from baseline, symptom improvement (e.g., discomfort, bleeding), and to monitor the safety and tolerability of the topical treatment over the study period.
All trial participants will receive treatment at no cost with the study medication for the duration of the study, as well as for an optional extension period afterward.
Compensation and reimbursement for travel to a study site for the study participant and a caregiver are provided by the study sponsor.
Additional information can be obtained from the national clinical study registry, Clinicaltrials.gov (Click the link below for more information:
NCT07552077).
Why Should I Participate in the LOTU Trial?
- The study medication is a gel that the patient can easily apply to their skin on their own once a day at home.
- You will be treated by a doctor at a nationally renowned medical center.
- All appointments, including travel and lodging for the participant and one caregiver, are provided at no cost, and you will also receive compensation for taking part in the study.
- You will be helping to find an effective treatment for Clinically Significant Angiokeratomas for patients like you.
See if you are Eligible
A Confirmed Angiokeratoma Diagnosis Condition
Patients Must be at least 6 Years Old or Older
Affected areas may include genitalia, arms, hand/fingers, chest, back/or leg or anywhere on the body.
Where is the LOTU Trial Taking Place?
Check the map below to see if there is a trial location close to you.
Compensation + Reimbursement for Travel and Lodging is available for the Participant and 1 Caregiver from anywhere within the U.S. or Canada.
Vivida Dermatology
Las Vegas, NV
Cleaver Dermatology
Dawsonville, GA
Epiphany Dermatology
Dallas, TX
Cura Clinical Research
Sherman Oaks, CA
MDCS Dermatology
Clifton, NJ (NY)
University of Rochester Medical Center
Rochester, NY
Children's Hospital of Orange County
Orange County, CA
Frequently Asked Questions
What are Clinically Significant Angiokeratomas ?
Clinically Significant Angiokeratomas are a type of vascular malformation caused by enlarged blood/lymphathic vessels close to the surface of the skin.
Angiokeratomas are usually dark red, purple, or black in color and may appear raised or rough on the skin. They can become painful, bleed easily, or grow in areas that are irritated by clothing or movement and may affect comfort, daily activities, or quality of life.lymphatic
What is a clinical trial?
A clinical trial, sometimes called a “study,” is the investigation of a medicine in a new way. Sometimes the medicine has been studied and approved for other diseases. Clinical trials in the United States are closely regulated by the Food & Drug Administration (FDA). Study participants and their doctors are provided with information specific to the trial to help them make a decision about whether the study is right for them.
What is the medicine being tested?
All patients in the LOTU Trial will treat themselves at home with a new gel formulation of an approved drug (rapamycin, also known as sirolimus). The gel will be rubbed onto the skin once a day by the participant, or for very young children, by their caregiver.
How much will participants be compensated for participating in the study?
Compensation is offered to offset patient burden and should not be considered the reason for participation. If you or your child is a good match for the study, the details related to the study stipend will be provided to you.
What if I don't see a location near me?
The study sponsor will pay travel expenses to a study location that is convenient for both the participant and one caregiver.
